ZnO NPs present certain cytotoxicity in cancer cells mainly by themselves based on a higher intracellular release of dissolved zinc ions, followed by increased ROS induction and induced cancer cell death via the apoptosis signaling pathway. established a new ZnO hollow nanocarrier (HZnO) engineered with biocompatible substrates by surface following conjugation with targeting agent folic acid (FA) and loaded with paclitaxel (PAC) to designate as the FCP-ZnO nanocomplex [48]. Abstract. fabricated two novel copolymer-encapsulated ZnO NPs for carrying curcumin, Cur/PMMA-PEG/ZnO NPs, and Cur/PMMA-AA/ZnO NPs nanocomposites [54, 55]. The conjugated ZnO-RSW displayed 61.93% of inhibition in glucosidase while the bare ZnO NPs and RSW showed 21.48% and 5.90%, respectively. It reported that ZnO NPs could significantly decrease malondialdehyde (MDA) and fast blood sugar and asymmetric dimethylarginine (ADMA) levels. Thatoi et al. The antibacterial effects of ZnO NPs in different bacterial species. Sharma et al. The upper part is the high-resolution transmission electron microscopy (HRTEM) image of the ZnO@polymer core-shell nanoparticles and the aqueous solutions of ZnO-1 and ZnO-2 under a UV light; the middle part is the DIC picture and the fluorescent image of the human hepatoma cells labeled by ZnO-1; and the lower part is the DIC picture and the fluorescent image of the hepatoma cells labeled by ZnO-2 [. 15k Accesses. … Zinc Oxide (ZnO) Nanoparticles – Properties & Applications. The antibacterial activity may involve the accumulation of ZnO NPs in the outer membrane or cytoplasm of bacterial cells and trigger Zn2+ release, which would cause bacterial cell membrane disintegration, membrane protein damage, and genomic instability, resulting in the death of bacterial cells [75–77]. It should be noted that S. aureus was more susceptible to Phβ-GBP-ZnO NPs than P. vulgaris. A. Sheikh, K. M. Hoque, and P. Chakrabarti, “The antimicrobial activity of ZnO nanoparticles against, K. Ghule, A. V. Ghule, B. J. Chen, and Y. C. Ling, “Preparation and characterization of ZnO nanoparticles coated paper and its antibacterial activity study,”, A. Iswarya, B. Vaseeharan, M. Anjugam et al., “Multipurpose efficacy of ZnO nanoparticles coated by the crustacean immune molecule beta-1,3-glucan binding protein: toxicity on HepG2 liver cancer cells and bacterial pathogens,”, M. Shaban, F. Mohamed, and S. Abdallah, “Production and characterization of superhydrophobic and antibacterial coated fabrics utilizing ZnO nanocatalyst,”, K. Karthik, S. Dhanuskodi, C. Gobinath, and S. Sivaramakrishnan, “Microwave-assisted synthesis of CdO-ZnO nanocomposite and its antibacterial activity against human pathogens,”, X. Bellanger, P. Billard, R. Schneider, L. Balan, and C. Merlin, “Stability and toxicity of ZnO quantum dots: Interplay between nanoparticles and bacteria,”, K. Dedkova, B. Janikova, K. 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Recently, nanomaterial-based nanomedicine, with high biocompatibility, easily surface functionalization, cancer targeting, and drug delivery capacity, has demonstrated the potential to overcome these side effects. From ICP-AES measurement, the amount of Zn2+ released from the small ZnO NPs were much higher than large ZnO powder sample and E. coli was more sensitive to Zn2+ than S. aureus. Zinc oxide (ZnO), as a material with attractive properties, has attracted great interest worldwide, particularly owing to the implementation of the synthesis of nano-sized particles. Jiang et al. Compared with other nanomaterials, ZnO NPs are attractive due to their low toxicity and biodegradable characteristics. Presently, Gram-negative Escherichia coli (E. coli) and Gram-positive Staphylococcus aureus (S. aureus) are mainly chosen as model bacteria to evaluate the antibacterial activity of ZnO NPs [77, 78]. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Using nanoparticles in targeted drug delivery provides exciting opportunities for much more safety and effective cancer treatment. Properties of Zinc Oxide Nanoparticles and Their Activity Against Microbes Khwaja Salahuddin Siddiqi1, Aziz ur Rahman2, Tajuddin2 and Azamal Husen3* Abstract Zinc oxide is an essential ingredient of many enzymes, sun screens, and ointments for pain and itch relief. ZnO NPs have been observed to show powerful cytotoxicity against MCF-7 cells, which was associated with the occurrence of apoptosis, more than cell cycle arrest. Campus Kumaun University, Almora 263601, India . investigated whether different-sized ZnO NPs would be able to penetrate injured skin and injured allergic skin in the mouse AD model [115]. Likewise, the relative level of LC3 II was comparatively higher in ZnO NPs treated cells than nontreated cells which also marked the extent of autophagy. Bell, D. G. Wingett, C. Hanley, and A. Punnoose, “Selective toxicity of zinc oxide nanoparticles to prokaryotic and eukaryotic systems,”, B. N. Singh, A. K. Rawat, W. Khan, A. H. Naqvi, and B. R. Singh, “Biosynthesis of stable antioxidant ZnO nanoparticles by, R. Ishwarya, B. Vaseeharan, S. Kalyani et al., “Facile green synthesis of zinc oxide nanoparticles using, T. Chatterjee, S. Chakraborti, P. Joshi, S. P. Singh, V. Gupta, and P. Chakrabarti, “The effect of zinc oxide nanoparticles on the structure of the periplasmic domain of the, Y. H. Hsueh, W. J. Ke, C. T. Hsieh, K. S. Lin, D. Y. Tzou, and C. L. Chiang, “ZnO nanoparticles affect, M. Divya, B. Vaseeharan, M. Abinaya et al., “Biopolymer gelatin-coated zinc oxide nanoparticles showed high antibacterial, antibiofilm and anti-angiogenic activity,”, I. Matai, A. Sachdev, P. Dubey, S. U. Kumar, B. Bhushan, and P. Gopinath, “Antibacterial activity and mechanism of Ag-ZnO nanocomposite on, S. Sarwar, S. Chakraborti, S. Bera, I. In order to improve the solubility and bioavailability of curcumin, Dhivya et al. found that ZnO NPs with a crystal size of 20 nm resulted in a concentration-dependent loss of ovarian cancer SKOV3 cell viability [51]. B. Patil, “Effect of morphology and crystallite size on solar photocatalytic activity of zinc oxide synthesized by solution free mechanochemical method,”, K. Elumalai and S. Velmurugan, “Green synthesis, characterization and antimicrobial activities of zinc oxide nanoparticles from the leaf extract of, C. Mahendra, M. Murali, G. Manasa et al., “Antibacterial and antimitotic potential of bio-fabricated zinc oxide nanoparticles of, G. Rajakumar, M. Thiruvengadam, G. Mydhili, T. Gomathi, and I. M. Chung, “Green approach for synthesis of zinc oxide nanoparticles from, Y. G. Qian, J. Yao, M. Russel, K. Chen, and X. Y. Wang, “Characterization of green synthesized nano-formulation (ZnO-A. It was found that zinc oxide calcined from 400°C to 550°C exhibited the same crystallite growth rate (38–50 nm) [22]. Copyright © 2018 Jinhuan Jiang et al. It has been found that PEG-ZnO NPs were active against most of the breast cancer cell lines. Inflammation is part of the complex biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or irritants [111]. Thus, ZnO in nanoscale has shown antimicrobial … Compared to 3T3-L1 cells, it appeared that ZnO NPs inhibited C2C12 cell proliferation and caused a marked apoptosis via a ROS-mediated mitochondrial intrinsic apoptotic pathway and p53, Bax/Bcl-2 ratio, and caspase-3 pathways [61]. In order to increase the targeting effects and selectivity against cancer cells, plenty of functionalization techniques have been reported for nanoparticle modification. Since the advent of nanoparticles and considering these biological activities of zinc ions, the anti-inflammatory effects of ZnO NPs have also attracted much attention. extracted crustacean immune molecule β-1,3-glucan binding protein (Phβ-GBP) from the heamolymph of Paratelphusa hydrodromus and then successfully fabricated the Phβ-GBP-coated ZnO NPs. It was worth to note that these nanoparticles did not show any remarkable toxicity for human hepatoma cells when their concentrations were less than 0.2 mg/mL. To stabilize ZnO NPs in water, they encapsulated the ZnO NPs with silica to form ZnO@silica core-shell nanostructures. RGD peptide-conjugated green fluorescent ZnO NWs can be specifically targeted to cell surface receptors in vitro [, P. K. Mishra, H. Mishra, A. Ekielski, S. Talegaonkar, and B. Vaidya, “Zinc oxide nanoparticles: a promising nanomaterial for biomedical applications,”, T. G. Smijs and S. Pavel, “Titanium dioxide and zinc oxide nanoparticles in sunscreens: focus on their safety and effectiveness,”, J. Given the known more anti-inflammatory activity of ZnO NPs, Nagajyothi et al. The ZnO-NPs demonstrated a far superior antioxidant and enzyme inhibition activity with a significantly lower IC50 value as compared to a standard reference. The addition of radical scavengers such as mannitol, vitamin E, and glutathione could block the bactericidal action of ZnO NPs, potentially revealing that ROS production played a necessary function in the antibacterial properties of ZnO NPs. The antibacterial potentiality of zinc oxide (ZnO) nanoparticles (NPs), compared with conventional ZnO powder, against nine bacterial strains, mostly foodborne including pathogens, was evaluated using qualitative and quantitative assays. Some other Gram-negative bacteria such as Pseudomonas aeruginosa (P. aeruginosa) [24, 79], Proteus vulgaris (P. vulgaris) [80], Vibrio cholerae (V. cholerae) [81] and other Gram-positive bacteria such as Bacillus subtilis (B. subtilis) [82] and Enterococcus faecalis (E. faecalis) [83] are also investigated. XRD and TEM confirmed the formation of nanosized zinc oxide particles in the size range of 18-31 nm. Abstract In this research, zinc oxide (ZnO) nanoparticles were prepared through a chemical co-precipitation route using zinc acetate dihydrate and sodium hydroxide as the reactants. Puvvada et al. Bai et al. vera) and their antibacterial activity against pathogens,”, K. Ali, S. Dwivedi, A. Azam et al., “Aloe vera extract functionalized zinc oxide nanoparticles as nanoantibiotics against multi-drug resistant clinical bacterial isolates,”, R. Yuvakkumar, J. Suresh, A. J. Nathanael, M. Sundrarajan, and S. I. Hong, “Novel green synthetic strategy to prepare ZnO nanocrystals using rambutan (, P. C. Nagajyothi, S. J. Cha, I. J. Yang, T. V. Sreekanth, K. J. Kim, and H. M. Shin, “Antioxidant and anti-inflammatory activities of zinc oxide nanoparticles synthesized using, A. C. Janaki, E. Sailatha, and S. Gunasekaran, “Synthesis, characteristics and antimicrobial activity of ZnO nanoparticles,”, R. Dobrucka and J. Dugaszewska, “Biosynthesis and antibacterial activity of ZnO nanoparticles using, D. Sharma, M. I. Sabela, S. Kanchi et al., “Biosynthesis of ZnO nanoparticles using, J. Qu, X. Yuan, X. H. Wang, and P. Shao, “Zinc accumulation and synthesis of ZnO nanoparticles using, H. Sharma, K. Kumar, C. Choudhary, P. K. Mishra, and B. Vaidya, “Development and characterization of metal oxide nanoparticles for the delivery of anticancer drug,”, Y. Zhang, T. R. Nayak, H. Hong, and W. Cai, “Biomedical applications of zinc oxide nanomaterials,”, M. Martinez-Carmona, Y. Gun’ko, and M. Vallet-Regi, “ZnO nanostructures for drug delivery and theranostic applications,”, I. Nanotechnology research has gained momentum in recent years providing innovative solutions in the field of biomedicine, materials science, optics and electronics. Hence, autophagy not only promotes cell survival but also activates lethal mechanisms in cancer cells, thus be considered as an important event in nanoparticle-induced cytotoxicity. Epidemic disease cholera, a serious diarrheal disease caused by the intestinal infection of Gram-negative bacterium V. cholera, mainly affects populations in the developing countries [81, 94]. By means of the experimental study, PMMA-PEG/ZnO nanocomposites with the average size less than 80 nm could release curcumin more quickly in the acidic conditions at pH ∼5.8. But up to now, the advanced anticancer mechanism study of ZnO NPs is still lacked of, especially in cellular and molecular mechanism strengthening. However, severely elicited oxidative stress particularly at higher doses was also observed by the altered erythrocyte antioxidant enzyme activities, increased in malondialdehyde (MDA) production, and marked reduction of serum total antioxidant capacity [100]. Jiang et al. Zinc is well known to keep the structural integrity of insulin and has an active role in the secretion of insulin from pancreatic cells. The mitochondrial electron transport chain is known to be associated with intracellular ROS generation, and anticancer agents entering into cancer cells could destroy the electron transport chain and release huge amounts of ROS [58, 59]. ZnO NPs have exhibited promising biomedical applications based on its anticancer, antibacterial, antidiabetic, anti-inflammatory, drug delivery, as well as bioimaging activity. carried out a detailed study about ZnO NPs against Vibrio cholerae (two biotypes of cholera bacteria (classical and El Tor)). ZnO NPs-exposed HepG2 cells presented higher cytotoxicity and genotoxicity, which were associated with cell apoptosis mediated by the ROS triggered mitochondrial pathway. A. Othman, C. Greenwood, A. F. Abuelela et al., “Correlative light-electron microscopy shows RGD-targeted ZnO nanoparticles dissolve in the intracellular environment of triple negative breast cancer cells and cause apoptosis with intratumor heterogeneity,”, N. Puvvada, S. Rajput, B. N. Kumar et al., “Novel ZnO hollow-nanocarriers containing paclitaxel targeting folate-receptors in a malignant pH-microenvironment for effective monitoring and promoting breast tumor regression,”, N. Tripathy, R. Ahmad, H. A. Ko, G. Khang, and Y. Department of Chemistry, Physical Chemistry Laboratory, S. S. J. CuO particles showed rod shaped/ellipsoid morphology. Download : Download high-res image (209KB)Download : Download full-size image. This research provided a novel insight into the regulation mechanisms of autophagy-lysosomes-mitochondria-ROS axis, which would contribute to a better understanding of the toxicity of nanomaterials. Abstract and Figures We report the synthesis and characterization of nanosized zinc oxide particles and their application on cotton and wool fabrics for UV shielding. We use cookies to help provide and enhance our service and tailor content and ads. So, as a type of safe and cheap luminescent labels, the ZnO@polymer core-shell nanoparticles can be used as fluorescent probes for cell imaging in vitro [121]. Research Paper: Chronic Zinc Oxide Nanoparticles Exposure Produces Hepatic and Pancreatic Impairment in Female Rats * Corresponding author: Seyed Mohammad Hosseini, PhD. constructed ZnO nanosheets for the imaging of cultured cells. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. Green synthesis of zinc oxide nanoparticles by Neem extract as multi-facet therapeutic agents. described a straightforward, inexpensive, and ecofriendly ZnO NPs using the root extract of P. tenuifolia and the anti-inflammatory activities were investigated in LPS-stimulated RAW 264.7 macrophages [30]. The central attention is on the functionalization of the ZnO NPs surface with different kinds of biological molecules comprising different types of proteins, peptides, nucleic acids, folic acid, hyaluronan, and so on [47, 57, 71–73]. Following studies focused on the abovementioned issues could further elucidate and comprehend the potential use of ZnO nanoparticles in biomedical diagnostic and therapeutic fields. Toxicity of zinc oxide nanoparticles is concentration and solubility dependent. Zn2+ is an essential nutrient for adults, and ZnO nanomaterials are considered to be safe in vivo. In general, the anticancer activity of nanoscaled ZnO materials with prominent functionality may provide a new opportunity for exploiting ZnO NPs in treating cancer diseases. Recently, titanium dioxide (TiO 2) and zinc oxide (ZnO) nanoparticles (NPs) have gained popularity as inorganic physical sunscreens because they can reflect and scatter UVA and UVB radiations while preventing skin irritation and disruption of the endocrine system typically induced by chemical UV filters. Reprinted with permission from, T. Andelman et al., J. Phys. Compared to bare ZnO NPs, RGD peptide modification also increased the targeting effects of ZnO NPs on integrin αvβ3 receptors overexpressed MDA-MB-231 cells [47]. 028/2014/A1) and China Postdoctoral Science Foundation (2018M631026). The aim of this study was the evaluation of the antitumor efficacy of zinc oxide nanoparticle (ZnO-NPs) and sorafenib alone or in combination on solid Ehrlich carcinoma (SEC) in mice. The exact physical and chemical properties of zinc oxide nanoparticles depend on the different ways they are synthesized. Optical properties can be tuned by doping. This is a possibly due to the high antioxidative and strong antibacterial capacity of the ZnO textile. Park, “Functionalized ZnO nanoparticles with gallic acid for antioxidant and antibacterial activity against methicillin-resistant, T. Ohira and O. Yamamoto, “Correlation between antibacterial activity and crystallite size on ceramics,”, S. Sarwar, A. Ali, M. Pal, and P. Chakrabarti, “Zinc oxide nanoparticles provide anti-cholera activity by disrupting the interaction of cholera toxin with the human GM1 receptor,”, S. N. Seclen, M. E. Rosas, A. J. Arias, and C. A. Medina, “Elevated incidence rates of diabetes in Peru: report from PERUDIAB, a national urban population-based longitudinal study,”, A. Nazarizadeh and S. Asri-Rezaie, “Comparative study of antidiabetic activity and oxidative stress induced by zinc oxide nanoparticles and zinc sulfate in diabetic rats,”, R. D. Umrani and K. M. Paknikar, “Zinc oxide nanoparticles show antidiabetic activity in streptozotocin-induced Type 1 and 2 diabetic rats,”, R. Malizia, A. Scorsone, P. D’Angelo, C. Lo Pinto, L. Pitrolo, and C. Giordano, “Zinc deficiency and cell-mediated and humoral autoimmunity of insulin-dependent diabetes in thalassemic subjects,”, R. Kitture, K. Chordiya, S. Gaware et al., “ZnO nanoparticles-red sandalwood conjugate: a promising anti-diabetic agent,”, J. Hussein, M. El-Banna, T. A. Razik, and M. E. El-Naggar, “Biocompatible zinc oxide nanocrystals stabilized via hydroxyethyl cellulose for mitigation of diabetic complications,”, A. Bayrami, S. Parvinroo, A. Habibi-Yangjeh, and S. Rahim Pouran, “Bio-extract-mediated ZnO nanoparticles: microwave-assisted synthesis, characterization and antidiabetic activity evaluation,”, A. Amiri, R. A. F. Dehkordi, M. S. Heidarnejad, and M. J. Dehkordi, “Effect of the zinc oxide nanoparticles and thiamine for the management of diabetes in alloxan-induced mice: a stereological and biochemical study,”, N. S. Wahba, S. F. Shaban, A. Greater selectivity among normal and cancerous cells displayed different fluorescent colors with different emission wavelengths Macau Science Pollution! Patil synthesized ZnO NPs with sizes of ∼13 nm and examined their antibacterial ( coli... Bioavailability of curcumin, Cur/PMMA-PEG/ZnO NPs, and mouthwashes Science Foundation ( 2018M631026 ) were generally more sensitive to than... The NIH/3T3 cells surface and displayed different fluorescent colors with different morphologies and crystallite sizes using this exhibited! Surface area relative to their size and high catalytic activity nanomedicine against cholera Sarwar! ) through green synthesis for the removal of Cd ( II ) from heamolymph! 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